Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: GSVDSKYSSS FLDSGWRDLF SRSEPPVSEQ LDVAGRVMQY VNGAATTHQL P
Antigen sequence identity: Mouse 88%; Rat 88%
PACS-1 (CRA_a) is a 963 amino acid rich regulatory protein involved in protein trafficking and belongs to the PACS family. A coat protein involved in controlling the correct subcellular localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs, PACS-1 is also known to be involved in HIV-1 Nef-mediated removal of MHC-I from the cell surface to the TGN, thus enabling HIV-1 to escape immune surveillance. PACS-1 also controls the endosome to Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin coated membrane pits. Usually seen in golgi apparatus, trans-Golgi network and localized in the paranuclear region, it is ubiquitously expressed in most of the tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cytosolic sorting protein PACS-1; PACS-1; Phosphofurin acidic cluster sorting protein 1
Gene Aliases: KIAA1175; MRD17; PACS1
UniProt ID: (Human) Q6VY07
Entrez Gene ID: (Human) 55690
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support