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PACSIN 2, a 486 AA phosphoprotein is a novel member of the PACSIN family of cytoplasmic adapter proteins. It is an isoform of PACSIN with a CDC15 N-terminal domain, a C-terminal SH3 domain, 3 conserved regions specific to the PACSIN family, and 3 asn-pro-phe (NPF) motifs, which potentially bind to EH domains. This protein is known to display a ubiquitous expression pattern with the highest levels of expression in brain. Reports suggest that PACSIN 2 participates in the organization of the actin cytoskeleton, the regulation of vesicular traffic. It also participates in endocytic internalization and endocytic receptor recycling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cytoplasmic phosphoprotein PACSIN2; Protein kinase C and casein kinase substrate in neurons protein 2; RP3-437M21.1; syndapin 2; Syndapin II; Syndapin-2; Syndapin-II; syndapin2
Gene Aliases: AI197433; PACSIN2; SDPII
UniProt ID: (Human) Q9UNF0, (Mouse) Q9WVE8
Entrez Gene ID: (Human) 11252, (Mouse) 23970
Molecular Function:
actin family cytoskeletal protein
cytoskeletal protein
membrane traffic protein
membrane trafficking regulatory protein
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