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Proteintech
PADI2 Polyclonal Antibody
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Product Details
12110-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Dog,
Human,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PADI2 Fusion Protein Ag2755 (118-438 aa encoded by BC009701)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ISLDVDADR DGVVEKNNPK KASWTWGPEG QGAILLVNCD RETPWLPKED CRDEKVYSKE DLKDMSQMIL RTKGPDRLPA GYEIVLYISM SDSDKVGVFY VENPFFGQRY IHILGRRKLY HVVKYTGGSA ELLFFVEGLC FPDEGFSGLV SIHVSLLEYM AQDIPLTPIF TDTVIFRIAP WIMTPNILPP VSVFVCCMKD NYLFLKEVKN LVEKTNCELK VCFQYLNRGD RWIQDEIEFG YIEAPHKGFP VVLDSPRDGN LKDFPVKELL GPDFGYVTRE PLFESVTSLD SFGNLEVSPP VTVNGKTYPL GRILIGSSFP L (118-438 aa encoded by BC009701)
Target Information
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PAD type II; PAD-H19; peptidyl arginine deiminase, type 2; peptidyl arginine deiminase, type II; peptidyl arginine deiminase, type II; PAD type II; Peptidylarginine deiminase II; Protein-arginine deiminase type II; Protein-arginine deiminase type-2; RP1-37C10.6
Gene Aliases: KIAA0994; mKIAA0994; PAD-H19; PAD2; PADI2; Pdi; PDI2
UniProt ID: (Human) Q9Y2J8, (Rat) P20717, (Mouse) Q08642
Entrez Gene ID: (Human) 11240, (Rat) 29511, (Mouse) 18600
regulation of chromatin disassembly
protein citrullination
substantia nigra development
intracellular estrogen receptor signaling pathway
histone H3-R26 citrullination
chromatin-mediated maintenance of transcription
negative regulation of chemokine-mediated signaling pathway
negative regulation of lymphocyte chemotaxis
chromatin organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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