This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: PWLPKEDCRD EKVYSKEDLK DMSQMILRTK GPDRLPAGYE IVLYISMSDS DKVGVFYVEN PFFGQRYIHI LGRRKLYHVV KYTGGS
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: PAD-H19; peptidyl arginine deiminase, type II; Peptidylarginine deiminase II; protein arginine deiminase; Protein-arginine deiminase type II; Protein-arginine deiminase type-2; RP1-37C10.6, KIAA0994, PAD-H19, PAD2, PDI2, peptidlyarginine deiminase type II
Gene Aliases: KIAA0994; PAD-H19; PAD2; PADI2; PDI2
UniProt ID: (Human) Q9Y2J8
Entrez Gene ID: (Human) 11240
Molecular Function: hydrolase