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Product Details
15441-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PAF1 Fusion Protein Ag7212 (166-531 aa encoded by BC000017) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.24 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
The MW of this protein is 80 kDa, and this antibody specifically recognizes the 80 kDa protein.
Immunogen sequence: EEIYKDRDS QITAIEKTFE DAQKSISQHY SKPRVTPVEV MPVFPDFKMW INPCAQVIFD SDPAPKDTSG AAALEMMSQA MIRGMMDEEG NQFVAYFLPV EETLKKRKRD QEEEMDYAPD DVYDYKIARE YNWNVKNKAS KGYEENYFFI FREGDGVYYN ELETRVRLSK RRAKAGVQSG TNALLVVKHR DMNEKELEAQ EARKAQLENH EPEEEEEEEM ETEEKEAGGS DEEQEKGSSS EKEGSEDEHS GSESEREEGD RDEASDKSGS GEDESSEDEA RAARDKEEIF GSDADSEDDA DSDDEDRGQA QGGSDNDSDS GSNGGGQRSR SHSRSASPFP SGSEHSAQED GSEAAASDSS EADSDSD (166-531 aa encoded by BC000017 )
Target Information
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hPAF1; Paf1, RNA polymerase II associated factor, homolog; Pancreatic differentiation protein 2; RNA polymerase II-associated factor 1 homolog
Gene Aliases: F23149_1; PAF1; PD2
UniProt ID: (Human) Q8N7H5
Entrez Gene ID: (Human) 54623
negative regulation of transcription from RNA polymerase II promoter
endodermal cell fate commitment
transcription elongation from RNA polymerase II promoter
mRNA polyadenylation
histone monoubiquitination
Wnt signaling pathway
nucleosome positioning
stem cell population maintenance
positive regulation of histone methylation
positive regulation of mRNA 3'-end processing
positive regulation of transcription elongation from RNA polymerase II promoter
histone H2B ubiquitination
protein localization to nucleus
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to lipopolysaccharide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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