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Invitrogen
PAF1 Polyclonal Antibody
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Product Details
PA5-30751
Product Specifications
Species Reactivity
Human,
Mouse,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PAF1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Amount
37 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (92%), Xenopus laevis (93%), Chimpanzee (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hPAF1; Paf1, RNA polymerase II associated factor, homolog; paf1, RNA polymerase II associated factor, homolog, like; Pancreatic differentiation protein 2; PD2-like protein; RNA polymerase II-associated factor 1 homolog; unnamed protein product
Gene Aliases: 5730511K23Rik; AA675045; F23149_1; im:6906070; PAF1; paf1l; PD2; wu:fb80a09
UniProt ID: (Human) Q8N7H5, (Mouse) Q8K2T8, (Zebrafish) Q4U0S5
Entrez Gene ID: (Human) 54623, (Mouse) 54624, (Zebrafish) 553020
negative regulation of transcription from RNA polymerase II promoter
endodermal cell fate commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
mRNA polyadenylation
histone monoubiquitination
Wnt signaling pathway
nucleosome positioning
stem cell population maintenance
positive regulation of histone methylation
positive regulation of mRNA 3'-end processing
positive regulation of transcription elongation from RNA polymerase II promoter
histone H2B ubiquitination
protein localization to nucleus
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to lipopolysaccharide
transcription elongation from RNA polymerase II promoter
mRNA 3'-end processing
positive regulation of cell cycle G1/S phase transition
heart development
histone modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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