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Invitrogen
PAICS Polyclonal Antibody
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Product Details
PA5-57452
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PAICS. Recombinant protein control fragment (Product #RP-96643).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ETAFIAPQCE MIPIEWVCRR IATGSFLKRN PGVKEGYKFY PPKVELFFKD DANNDPQWSE EQLIAAKFCF AGLLIGQTEV DIMS
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AIR carboxylase; Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; multifunctional protein ADE2; multifunctional protein ADE2H1; PAICS; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase; SAICAR synthetase
Gene Aliases: 2610511I09Rik; ADE2; ADE2H1; AIRC; PAICS; PAIS
UniProt ID: (Human) P22234, (Rat) P51583, (Mouse) Q9DCL9
Entrez Gene ID: (Human) 10606, (Rat) 140946, (Mouse) 67054
phosphoribosylaminoimidazole carboxylase activity
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
protein binding
ATP binding
identical protein binding
cadherin binding involved in cell-cell adhesion
molecular_function
nucleotide binding
catalytic activity
lyase activity
carboxy-lyase activity
ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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