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Proteintech
PAK4 Polyclonal Antibody
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Product Details
14685-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PAK4 Fusion Protein Ag5981 (1-350 aa encoded by BC025282)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MFGKRKKRV EISAPSNFEH RVHTGFDQHE QKFTGLPRQW QSLIEESARR PKPLVDPACI TSIQPGAPKT IVRGSKGAKD GALTLLLDEF ENMSVTRSNS LRRDSPPPPA RARQENGMPE EPATTARGGP GKAGSRGRFA GHSEAGGGSG DRRRAGPEKR PKSSREGSGG PQESSRDKRP LSGPDVGTPQ PAGLASGAKL AAGRPFNTYP RADTDHPSRG AQGEPHDVAP NGPSAGGLAI PQSSSSSSRP PTRARGAPSP GVLGPHASEP QLAPPACTPA APAVPGPPGP RSPQREPQRV SHEQFRAALQ LVVDPGDPRS YLDNFIKIGE GSTGIVCIAT VRSSGKLVAV K (1-350 aa encoded by BC025282)
Target Information
PAK4 is a serine/ threonine p21 activating kinase implicated in the reorganization of actin cytoskeleton and in the formation of filopodia. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. The second group includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: p21 (CDKN1A)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; PAK-4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; Serine/threonine-protein kinase PAK 4
Gene Aliases: 5730488L07Rik; AW555722; KIAA1142; mKIAA1142; PAK4
UniProt ID: (Human) O96013, (Mouse) Q8BTW9
Entrez Gene ID: (Human) 10298, (Mouse) 70584, (Rat) 292756
mitotic cell cycle
apoptotic process
movement of cell or subcellular component
cytoskeleton organization
signal transduction
cell proliferation
cell growth
cell migration
signal transduction by protein phosphorylation
dendritic spine development
cellular response to organic cyclic compound
cell-cell adhesion
protein phosphorylation
Rho protein signal transduction
regulation of mitotic cell cycle
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
regulation of MAPK cascade
intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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