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Invitrogen
PAM Polyclonal Antibody
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FIGURE: 1 / 3
PAM Antibody (PA5-103032) in IHC (P)
Immunohistochemistry analysis of PAM in human pancreatic cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PAM polyclonal antibody (Product # PA5-103032) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103032
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PAM(Accession P19021), corresponding to amino acid residues E417-T467.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PAM.
Target Information
SNX33 (sorting nexin-33), also known as SH3PX3, SH3PXD3C or SNX30, is a 574 amino acid protein that interacts with ADAM15 and FAS-L. Belonging to the sorting nexin family, SNX33 contains one BAR domain, one PX (phox homology) domain and one SH3 domain. The gene that encodes SNX33 consists of over 14,000 bases and maps to human chromosome 15q24.2. Housing approximately 106 million base pairs and encoding more than 700 genes, chromosome 15 makes up about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PAM; pancreatic peptidylglycine alpha-amidating monooxygenase; peptidyl alpha-amidating enzyme; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Peptidyl-glycine alpha-amidating monooxygenase; PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PRECURSOR (PAM); peptidylamidoglycolate lyase; peptidylglycine 2-hydroxylase; Peptidylglycine alpha-amidating monooxygenase; peptidylglycine alpha-hydroxylating monooxygenase
Gene Aliases: PAL; PAM; PHM
UniProt ID: (Human) P19021, (Rat) P14925, (Mouse) P97467
Entrez Gene ID: (Human) 5066, (Rat) 25508, (Mouse) 18484
peptidylglycine monooxygenase activity
peptidylamidoglycolate lyase activity
copper ion binding
calcium ion binding
protein binding
zinc ion binding
protein kinase binding
L-ascorbic acid binding
catalytic activity
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
lyase activity
metal ion binding
oxygenase
peptide amidation
response to hypoxia
long-chain fatty acid metabolic process
regulation of transcription from RNA polymerase II promoter
central nervous system development
heart development
lactation
response to pH
toxin metabolic process
protein amidation
ovulation cycle process
response to estradiol
regulation of actin cytoskeleton organization
odontogenesis
response to drug
response to copper ion
regulation of protein secretion
protein homooligomerization
response to glucocorticoid
oxidation-reduction process
maternal process involved in female pregnancy
limb development
peptide metabolic process
protein metabolic process
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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