Recommended positive controls: Jurkat.
Predicted reactivity: Mouse (99%), Rat (98%), Chicken (93%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
Protein Aliases: Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB-dependent poly(A)-specific ribonuclease subunit 2; PAB1P-dependent poly(A)-nuclease; PAB1P-dependent poly(A)-specific ribonuclease; PABP-dependent poly(A) nuclease 2; PAN deadenylation complex catalytic subunit 2; PAN deadenylation complex subunit 2; PAN2 poly(A) specific ribonuclease subunit homolog; PAN2 polyA specific ribonuclease subunit; PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Poly(A)-nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52
Gene Aliases: KIAA0710; PAN2; USP52
UniProt ID: (Human) Q504Q3
Entrez Gene ID: (Human) 9924
Molecular Function: exoribonuclease