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Product Details
11001-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PANK2 Fusion Protein Ag1413 (328-570 aa encoded by BC009421)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IGDLQLCKL DELDCLIKGI LYIDSVGFNG RSQCYYFENP ADSEKCQKLP FDLKNPYPLL LVNIGSGVSI LAVYSKDNYK RVTGTSLGGG TFFGLCCLLT GCTTFEEALE MASRGDSTKV DKLVRDIYGG DYERFGLPGW AVASSFGNMM SKEKREAVSK EDLARATLIT ITNNIGSIAR MCALNENINQ VVFVGNFLRI NTIAMRLLAY ALDYWSKGQL KALFSEHEGY FGAVGALLEL LKIP (328-570 aa encoded by B C009421)
Target Information
Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hallervorden-Spatz syndrome; hPanK2; pantothenate kinase 2 (Hallervorden-Spatz syndrome); Pantothenate kinase 2, mitochondrial; Pantothenic acid kinase 2
Gene Aliases: 4933409I19Rik; AI642621; C20orf48; HARP; HSS; NBIA1; PANK2; PKAN
UniProt ID: (Human) Q9BZ23, (Mouse) Q7M753
Entrez Gene ID: (Human) 80025, (Rat) 296167, (Mouse) 74450
spermatid development
aerobic respiration
coenzyme biosynthetic process
coenzyme A biosynthetic process
pantothenate metabolic process
phosphorylation
regulation of fatty acid metabolic process
regulation of mitochondrial membrane potential
mitochondrion morphogenesis
regulation of triglyceride metabolic process
regulation of bile acid metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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