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Invitrogen
PANK2 Polyclonal Antibody
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FIGURE: 1 / 1
PANK2 Antibody (PA5-116847) in WB
Western blot analysis of PANK2 in extracts of Mouse lung. Samples were incubated with PANK2 Polyclonal antibody (Product # PA5-116847) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-116847
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PANK2 (NP_7059022)
Conjugate
Form
Liquid
Concentration
1.52 mg/mL
Amount
152 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse lung
Immunogen sequence: RDKNFSSLHT VFCATGGGAY KFEQDFLTIG DLQLCKLDEL DCLIKGILYI DSVGFNGRSQ CYYFENPADS EKCQKLPFDL KNPYPLLLVN IGSGVSILAV Y
Target Information
Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hPanK2; pantothenate kinase 2 (Hallervorden-Spatz syndrome); Pantothenate kinase 2, mitochondrial; Pantothenic acid kinase 2
Gene Aliases: 4933409I19Rik; AI642621; Pank2
UniProt ID: (Mouse) Q7M753
Entrez Gene ID: (Mouse) 74450
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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