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Proteintech
PAOX Polyclonal Antibody
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Product Details
18972-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PAOX Fusion Protein Ag5777 (31-364 aa encoded by BC032778)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RLCGHSAFP HLRVLEATAR AGGRIRSERC FGGVVEVGAH WIHGPSRGNP VFQLAAEYGL LGEKELSQEN QLVETGGHVG LPSVSYASSG ASVSLQLVAE MATLFYGLID QTREFLHAAE TPVPSVGEYL KKEIGQHVAG WTEDEETRKL KLAVLNSFFN LECCVSGTHS MDLVALAPFG EYTVLPGLDC TFSKGYQGLT NCMMAALPED TVVFEKPVKT IHWNGSFQEA AFPGETFPVS VECEDGDRFP AHHVIVTVPL GFLREHLDTF FDPPLPAEKA EAIRKIGFGT NNKIFLEFEE PFWEPDCQLI QLVWEDTSPL EDAAPELQDA WFRKL (31-364 aa encoded by B C032778)
Target Information
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: exo-N4-amino; Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; putative GTP-binding protein
Gene Aliases: 2410012F02Rik; AI118225; PAO; PAOX; UNQ1923/PRO4398
UniProt ID: (Human) Q6QHF9, (Mouse) Q8C0L6
Entrez Gene ID: (Human) 196743, (Mouse) 212503, (Rat) 293589
receptor binding
polyamine oxidase activity
N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
spermine:oxygen oxidoreductase (spermidine-forming) activity
spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
oxidoreductase activity
oxidase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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