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Fabgennix

PAR1 Polyclonal Antibody

View all (22) PAR1 antibodies

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Product Details

PAR1-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 390-440 on mouse PAR1 protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface G-protein coupled receptors which include PAR-1, PAR-2 and PAR3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C HTR; Coagulation factor II receptor; PAR-1; PIG18A; protease-activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor; unnamed protein product

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Gene Aliases: AI482343; CF2R; F2R; HTR; PAR-1; PAR1; ThrR; TR; TRGPC

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UniProt ID: (Human) P25116, (Mouse) P30558

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Entrez Gene ID: (Human) 2149, (Mouse) 14062, (Rat) 25439

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Function(s)
G-protein alpha-subunit binding G-protein coupled receptor activity receptor binding protein binding thrombin receptor activity G-protein beta-subunit binding signal transducer activity heterotrimeric G-protein binding G-protein coupled receptor
Process(es)
connective tissue replacement involved in inflammatory response wound healing negative regulation of glomerular filtration inflammatory response signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration establishment of synaptic specificity at neuromuscular junction blood coagulation hemostasis positive regulation of cell proliferation negative regulation of cell proliferation response to wounding anatomical structure morphogenesis glutamate secretion platelet activation regulation of blood coagulation positive regulation of blood coagulation positive regulation of cell migration response to lipopolysaccharide regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of collagen biosynthetic process positive regulation of Rho protein signal transduction dendritic cell homeostasis positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade negative regulation of neuron apoptotic process cell-cell junction maintenance positive regulation of transcription, DNA-templated positive regulation of vasoconstriction positive regulation of smooth muscle contraction positive regulation of JAK-STAT cascade regulation of synaptic plasticity homeostasis of number of cells within a tissue release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling positive regulation of calcium ion transport platelet dense granule organization regulation of biological quality positive regulation of ERK1 and ERK2 cascade thrombin receptor signaling pathway trans-synaptic signaling by endocannabinoid, modulating synaptic transmission negative regulation of renin secretion into blood stream activation of MAPKK activity activation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase C-activating G-protein coupled receptor signaling pathway tyrosine phosphorylation of STAT protein STAT protein import into nucleus positive regulation of phosphatidylinositol 3-kinase signaling obsolete death positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of sensory perception of pain positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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