Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%) Bovine, Hamster, Rabbit (94%) Marmoset, Elephant, Panda, Pig, Opossum (89%) Mouse, Dog (83%).
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
Protein Aliases: coagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; PAR-2; protease-activated receptor 2; Proteinase-activated receptor 2; Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2; Thrombin receptor-like 1
Gene Aliases: F2RL1; GPR11; PAR2
UniProt ID: (Human) P55085
Entrez Gene ID: (Human) 2150