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Alomone Labs, LTD

PAR2/F2RL1 (extracellular) Polyclonal Antibody, FITC

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

APR-035-F-50UL

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide KDIKEKSNVGMEFK, corresponding to amino acid residues 155-169 of mouse GPR171. 2nd extracellular loop.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Lyophilized

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunogen sequence: KDIKEKSNVGMEFK

Reconstitution: 50 uL double distilled water (DDW). The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: coagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; PAR-2; protease-activated receptor 2; Proteinase-activated receptor 2; Thrombin receptor-like 1

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Gene Aliases: F2RL1; GPR11; PAR2

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UniProt ID: (Human) P55085

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Entrez Gene ID: (Human) 2150

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Function(s)
G-protein alpha-subunit binding receptor activity G-protein coupled receptor activity receptor binding protein binding thrombin receptor activity G-protein beta-subunit binding G-protein coupled receptor
Process(es)
T cell activation involved in immune response positive regulation of leukocyte chemotaxis positive regulation of cytokine secretion involved in immune response positive regulation of glomerular filtration inflammatory response G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration blood coagulation negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of phosphatidylinositol 3-kinase signaling regulation of blood coagulation positive regulation of cell migration positive regulation of actin filament depolymerization positive regulation of pseudopodium assembly positive regulation of superoxide anion generation positive regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of Rho protein signal transduction chemokine (C-C motif) ligand 2 secretion neutrophil activation regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of eosinophil degranulation innate immune response positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter regulation of JNK cascade negative regulation of JNK cascade positive regulation of JNK cascade interleukin-1 beta secretion leukocyte migration positive regulation of chemotaxis positive regulation of positive chemotaxis defense response to virus positive regulation of phagocytosis, engulfment establishment of endothelial barrier positive regulation of ERK1 and ERK2 cascade thrombin receptor signaling pathway leukocyte proliferation positive regulation of neutrophil mediated killing of gram-negative bacterium interleukin-10 secretion interferon-gamma secretion chemokine secretion negative regulation of chemokine secretion mature conventional dendritic cell differentiation positive regulation of renin secretion into blood stream positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion
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