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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues M(1) A T G G Y R(7) C V(334) V G Q L T R(340) of the N- and C-termini of human Par4.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4217 detects the Par-4 protein in human samples.
PA1-4217 has been successfully used in Western blot procedures.
The PA1-4217 immunogen is a synthetic peptide corresponding to residues M(1) A T G G Y R(7) C V(334) V G Q L T R(340) of the N- and C-termini of human Par4, separated by a cysteine.
Prostate apoptosis response protein (Par-4) is an ~38 kDa protein containing a leucine zipper at its carboxy terminus. The leucine zipper is required for Par-4 function during apoptosis and has also been shown to directly interact with Wilm"e;s Tumor Suppressor, WT-1. Par-4 is up-regulated in apoptotic prostate cells and has also been observed at ~18 times higher concentration in human brain tissue from Alzheimer's patients when compared to unaffected brain tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
PAWR; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; Prostate Apoptosis Response-4; transcriptional repressor PAR4; WT1-interacting protein
Par-4; PAR4; PAWR