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Invitrogen
PAR4 Polyclonal Antibody
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Product Details
PA1-755
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic Peptide: C E(322) Q L K Q E N K T L L K V V G Q L T R(340)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-755 detects prostate apoptosis response protein (Par-4) from human and rat tissues.
PA1-755 has been sucessfully used in Western blot procedures. By Western blot, this antibody detects an ~40 kDa protein representing Par-4 in AT-3 cell extract. In Western blots of rat tissue extracts, including testes, spleen, ovary, lung, and skeletal muscle, ~40 kDa and ~38 kDa proteins representing Par-4 are detected. In Western blots of T47D cell extracts, an ~40 kDa protein representing Par-4 and a smaller ~20 kDa unknown protein is detected.
PA1-755 immunizing peptide corresponds to amino acids residues 322-340 from human Par-4. PA1-755 immunizing peptide (Cat. # PEP-060) is available for use in neutralization and control experiments.
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Par-4; par-4 induced by effectors of apoptosis; PAWR; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4; Prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; Transcriptional repressor Par-4-like protein PAWR; transcriptional repressor PAR4; WT1-interacting protein
Gene Aliases: Par-4; PAR4; PAWR
UniProt ID: (Human) Q96IZ0, (Rat) Q62627
Entrez Gene ID: (Human) 5074, (Rat) 64513
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
negative regulation of B cell proliferation
interleukin-2 biosynthetic process
negative regulation of T cell proliferation
positive regulation of amyloid precursor protein biosynthetic process
negative regulation of T cell receptor signaling pathway
actin filament bundle assembly
apoptotic signaling pathway
negative regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
negative regulation of gene expression
positive regulation of apoptotic process
negative regulation of fibroblast proliferation
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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