This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 domain and a semi-Cdc42/Rac interactive binding domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Protein Aliases: PAR-6; par-6 (partitioning defective 6, C.elegans) homolog alpha; PAR-6 alpha; par-6 partitioning defective 6 homolog alpha; par-6 partitioning defective 6 homolog alpha (C.elegans); PAR-6A; PAR6; PAR6alpha; PAR6C; PARD6A; Partitioning defective 6 homolog alpha; partitioning defective-6 homolog alpha; partitioning-defective protein 6; Tax interaction protein 40; Tax-interacting protein 40; TAX40; TIP-40
Gene Aliases: PAR-6A; PAR6; PAR6A; PAR6alpha; PAR6C; PARD6A; TAX40; TIP-40
UniProt ID: (Human) Q9NPB6
Entrez Gene ID: (Human) 50855