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PARK-7 Polyclonal Antibody

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PARK-7 Polyclonal Antibody

Product Details

600-401-691

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500- 1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-

ELISA (ELISA)

1:10,000-1:50,000
-

Immunoprecipitation (IP)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Chimpanzee, Human, Non-human primate, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of Human PARK7 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.3 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Reactivity occurs against human PARK7 protein. BLAST analysis was used to determine that 100% homology with the immunizing peptide sequence is on record for this protein from human, chimpanzee, African green monkey, zebrafish and also for mutant/variant forms of human DJ-1 protein. Cross reactivity with PARK7 from frog, mouse, rat, dog, chicken, Japanese rice fish and Atlantic salmon may also occur as the sequence varies by only one amino acid residue as indicated by BLAST analysis. Reactivity with PARK7 protein from other sources is not known.

Target Information

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CTA-215D11.1; DJ-1; DJ-1 protein; early onset 7; epididymis secretory sperm binding protein Li 67p; FLJ27376; FLJ34360; FLJ92274; Maillard deglycase; Oncogene DJ1; OTTHUMP00000001350; OTTHUMP00000001351; PARK7 GENE; PARK7/DJ1; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; Parkinson disease protein 7 homolog; parkinson protein 7; Parkinsonism-associated deglycase; protein deglycase DJ-1; protein deglycase DJ-1zDJ-1; Protein DJ-1; Protein DJ-1zDJ-1; Protein/nucleic acid deglycase DJ-1; unnamed protein product; zDJ-1

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Gene Aliases: DJ-1; DJ1; GATD2; HEL-S-67p; PARK7; zgc:103725

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UniProt ID: (Human) Q99497, (Zebrafish) Q5XJ36

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Entrez Gene ID: (Human) 11315, (Zebrafish) 449674

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Function(s)
core promoter sequence-specific DNA binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity RNA binding mRNA binding receptor binding copper ion binding protein binding enzyme activator activity peptidase activity superoxide dismutase copper chaperone activity oxidoreductase activity, acting on peroxide as acceptor hydrolase activity oxygen sensor activity enzyme binding kinase binding cytokine binding peptidase inhibitor activity receptor activator activity tyrosine 3-monooxygenase activator activity L-dopa decarboxylase activator activity protein deglycase activity identical protein binding protein homodimerization activity small protein activating enzyme binding ubiquitin-like protein conjugating enzyme binding cadherin binding mercury ion binding androgen receptor binding peroxiredoxin activity ubiquitin-protein transferase inhibitor activity scaffold protein binding DNA-binding transcription factor binding cupric ion binding cuprous ion binding ubiquitin-specific protease binding glyoxalase (glycolic acid-forming) activity
Process(es)
DNA repair proteolysis protein deglycosylation autophagy inflammatory response response to oxidative stress single fertilization methylglyoxal metabolic process insulin secretion cellular response to oxidative stress protein deglycation, glyoxal removal protein deglycation, methylglyoxal removal glucose homeostasis regulation of neuron apoptotic process protein stabilization negative regulation of cell death cellular response to hydrogen peroxide guanine deglycation, methylglyoxal removal guanine deglycation, glyoxal removal negative regulation of reactive oxygen species biosynthetic process positive regulation of oxidative phosphorylation uncoupler activity synaptic transmission, dopaminergic positive regulation of acute inflammatory response to antigenic stimulus cellular response to DNA damage stimulus mitochondrion organization Ras protein signal transduction adult locomotory behavior detoxification of copper ion positive regulation of gene expression negative regulation of gene expression lactate biosynthetic process removal of superoxide radicals protein repair androgen receptor signaling pathway positive regulation of protein complex assembly negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of TRAIL production positive regulation of interleukin-8 production negative regulation of protein sumoylation cellular response to reactive oxygen species cellular response to glyoxal negative regulation of protein catabolic process response to hydrogen peroxide hydrogen peroxide metabolic process negative regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter glycolate biosynthetic process negative regulation of protein export from nucleus regulation of inflammatory response detoxification of mercury ion dopamine uptake involved in synaptic transmission regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling membrane depolarization membrane hyperpolarization regulation of androgen receptor signaling pathway detoxification of hydrogen peroxide methylglyoxal catabolic process to lactate detection of oxidative stress guanine deglycation cellular detoxification of aldehyde cellular detoxification of methylglyoxal positive regulation of protein localization to nucleus regulation of synaptic vesicle endocytosis negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of fibril organization positive regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of death-inducing signaling complex assembly negative regulation of protein K48-linked deubiquitination negative regulation of TRAIL-activated apoptotic signaling pathway positive regulation of dopamine biosynthetic process glyoxal metabolic process glyoxal catabolic process positive regulation of L-dopa biosynthetic process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway positive regulation of reactive oxygen species biosynthetic process positive regulation of mitophagy negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway
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