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Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Reactivity occurs against human PARK7 protein. BLAST analysis was used to determine that 100% homology with the immunizing peptide sequence is on record for this protein from human, chimpanzee, African green monkey, zebrafish and also for mutant/variant forms of human DJ-1 protein. Cross reactivity with PARK7 from frog, mouse, rat, dog, chicken, Japanese rice fish and Atlantic salmon may also occur as the sequence varies by only one amino acid residue as indicated by BLAST analysis. Reactivity with PARK7 protein from other sources is not known.
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
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Protein Aliases: CTA-215D11.1; DJ-1; DJ-1 protein; early onset 7; epididymis secretory sperm binding protein Li 67p; FLJ27376; FLJ34360; FLJ92274; Maillard deglycase; Oncogene DJ1; OTTHUMP00000001350; OTTHUMP00000001351; PARK7 GENE; PARK7/DJ1; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; Parkinson disease protein 7 homolog; parkinson protein 7; Parkinsonism-associated deglycase; protein deglycase DJ-1zDJ-1; Protein DJ-1; Protein DJ-1zDJ-1; Protein/nucleic acid deglycase DJ-1; zDJ-1
Gene Aliases: DJ-1; DJ1; HEL-S-67p; PARK7; zgc:103725