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Invitrogen
PARL Polyclonal Antibody
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Product Details
PA5-20579
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide from near the amino terminus of human PARL.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Despite its predicted molecular weight of ~42kDa, PARL is observed at a higher molecular weight in SDS-PAGE. A suggested positive control is NIH-3T3 cell lysate.
PA5-20579 can be used with blocking peptide PEP-0699.
Target Information
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mitochondrial intramembrane cleaving protease PARL; Mitochondrial intramembrane-cleaving protease PARL; parl {ECO:0000250|UniProtKB:Q9H300}; Presenilin-associated rhomboid-like protein, mitochondrial; presenilins-associated rhomboid-like protein, mitochondrial; rhomboid 7 homolog 1
Gene Aliases: D16Ertd607e; PARL; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
UniProt ID: (Human) Q9H300, (Mouse) Q5XJY4, (Rat) Q3B8P0
Entrez Gene ID: (Human) 55486, (Mouse) 381038, (Rat) 287979
proteolysis
protein processing
regulation of proteolysis
membrane protein proteolysis
negative regulation of release of cytochrome c from mitochondria
regulation of mitophagy
regulation of protein targeting to mitochondrion
regulation of reactive oxygen species metabolic process
negative regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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