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PARP16 Polyclonal Antibody
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Product Details
BS-9623R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PARP16, amino acids 120-170.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP16 is a member of poly(ADP-ribose) polymerases (PARPs) family that is encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 15; mono [ADP-ribose] polymerase PARP16; PARP-16; Poly [ADP-ribose] polymerase 16; Protein mono-ADP-ribosyltransferase PARP16; unnamed protein product
Gene Aliases: ARTD15; BC055447; C15orf30; C79952; LRRGT00109; PARP-16; PARP16; pART15; RGD1306243
UniProt ID: (Human) Q8N5Y8, (Mouse) Q7TMM8, (Rat) Q5U2Q4
Entrez Gene ID: (Human) 54956, (Mouse) 214424, (Rat) 315760
NAD+ ADP-ribosyltransferase activity
protein binding
transferase activity
transferase activity, transferring glycosyl groups
nucleotidyltransferase activity
kinase binding
protein serine/threonine kinase activator activity
NAD+-protein-lysine ADP-ribosyltransferase activity
NAD+-protein-aspartate ADP-ribosyltransferase activity
NAD+-protein-glutamate ADP-ribosyltransferase activity
protein ADP-ribosylase activity
cytoplasmic translation
response to unfolded protein
viral protein processing
endoplasmic reticulum unfolded protein response
NAD salvage
IRE1-mediated unfolded protein response
protein auto-ADP-ribosylation
cellular response to leukemia inhibitory factor
negative regulation of cytoplasmic translation
protein ADP-ribosylation
activation of signaling protein activity involved in unfolded protein response
negative regulation of cell death
positive regulation of protein serine/threonine kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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