PASKIN (PAS-Kinase) is thought to regulate protein synthesis in cells. It is a conserved gene product found in yeast as well as mammals. PASKIN contains two domains (PAS A and PAS B) as well as a serine/threonine kinase domain related to AMP kinases. PASKIN activity leads to decreased carbohydrate storage, as well as increased protein synthesis. PASKIN-dependent phosphorylation inhibits the activity of mammalian glycogen synthase.
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Protein Aliases: OTTMUSP00000024404; PAS domain-containing serine/threonine-protein kinase; PAS-kinase; paskin; per-arnt-sim (PAS) domain kinase
Gene Aliases: KIAA0135; mKIAA0135; PASK; PASKIN; STK37