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Proteintech
PAWR Polyclonal Antibody
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Product Details
20688-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to PAWR.
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Par-4; par-4 induced by effectors of apoptosis; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4; Prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; Transcriptional repressor Par-4-like protein PAWR; transcriptional repressor PAR4; WT1-interacting protein
Gene Aliases: 2310001G03Rik; Par-4; PAR4; PAWR
UniProt ID: (Human) Q96IZ0, (Rat) Q62627, (Mouse) Q925B0
Entrez Gene ID: (Human) 5074, (Rat) 64513, (Mouse) 114774
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
apoptotic process
response to wounding
response to iron(II) ion
negative regulation of B cell proliferation
response to lipopolysaccharide
positive regulation of phosphoprotein phosphatase activity
interleukin-2 biosynthetic process
negative regulation of T cell proliferation
positive regulation of amyloid precursor protein biosynthetic process
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
negative regulation of T cell receptor signaling pathway
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
actin filament bundle assembly
positive regulation of hindgut contraction
cellular response to vitamin E
cellular response to interleukin-1
cellular response to follicle-stimulating hormone stimulus
cellular response to estradiol stimulus
negative regulation of calcium ion import
apoptotic signaling pathway
activation of cysteine-type endopeptidase activity
positive regulation of relaxation of smooth muscle
positive regulation of leukocyte tethering or rolling
positive regulation of neuronal action potential
calcium ion import into cell
positive regulation of neutrophil extravasation
regulation of transcription, DNA-templated
positive regulation of action potential
regulation of neuronal action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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