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Proteintech
PAWR Polyclonal Antibody
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Product Details
20688-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to PAWR.
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Par-4; par-4 induced by effectors of apoptosis; PAWR; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4; Prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; Transcriptional repressor Par-4-like protein PAWR; transcriptional repressor PAR4; WT1-interacting protein
Gene Aliases: 2310001G03Rik; Par-4; PAR4; PAWR
UniProt ID: (Human) Q96IZ0, (Rat) Q62627, (Mouse) Q925B0
Entrez Gene ID: (Human) 5074, (Rat) 64513, (Mouse) 114774
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
negative regulation of B cell proliferation
interleukin-2 biosynthetic process
negative regulation of T cell proliferation
positive regulation of amyloid precursor protein biosynthetic process
negative regulation of T cell receptor signaling pathway
actin filament bundle assembly
apoptotic signaling pathway
positive regulation of phosphoprotein phosphatase activity
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of action potential
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of hindgut contraction
negative regulation of calcium ion import
activation of cysteine-type endopeptidase activity
regulation of neuronal action potential
positive regulation of relaxation of smooth muscle
positive regulation of leukocyte tethering or rolling
calcium ion import into cell
positive regulation of neutrophil extravasation
negative regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
negative regulation of gene expression
negative regulation of fibroblast proliferation
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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