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Product Details
21386-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PAX3 Fusion Protein Ag16021 (341-426 aa encoded by BC101301)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.59 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: QSTIPSNPD SSSAYCLPST RHGFSSYTDS FVPPSGPSNP MNPTIGNGLS PQVMGLLTNH GGVPHQPQTD YALSPLTGGL EPTTTVS (341-426 aa encoded by BC101301 )
Target Information
Pax 3 (Paired Box 3) is a transcription factor that is involved in development of the peripheral nervous system, melanocytes, some vascular smooth muscle, and a number of other derivatives. It regulates neurogenesis in pre-migratory neural crest cells from the dorsal neural tube, and in myogenic progenitors in the presomitic mesoderm and the hypaxial somites. Alternative splicing results in isoforms having different C-termini.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: homeodomain protein PAX3; HuP2; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778; paired box gene 3; paired box homeotic gene 3; Paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; PAX3/FKHR fusion
Gene Aliases: CDHS; HUP2; Pax-3; PAX3; Sp; splotch; WS1; WS3
UniProt ID: (Human) P23760, (Mouse) P24610
Entrez Gene ID: (Human) 5077, (Rat) 114502, (Mouse) 18505
Molecular Function:
homeodomain transcription factor
transcription from RNA polymerase II promoter
apoptotic process
nervous system development
muscle organ development
sensory perception of sound
organ morphogenesis
neural crest formation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
neural tube closure
heart development
cell proliferation
positive regulation of cell proliferation
regulation of somitogenesis
cell migration
spinal cord association neuron differentiation
neural tube development
gliogenesis
developmental pigmentation
neuron fate commitment
skeletal muscle organ development
mammary gland specification
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
skeletal muscle cell differentiation
cardiac muscle cell differentiation
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