Invitrogen

PAX3 Polyclonal Antibody

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PAX3 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of PAX3 in Human Esophagus using a PAX3 monoclonal antibody (Product #PA5-18271) at 4.5 µg/mL. The Human Esophagus tissue section was paraffin embeded and detected using Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.

PAX3 Antibody in Western Blot (WB) — Western blot analysis of PAX3 in Human Duodenum lysate using a PAX3 polyclonal antibody (Product # PA5-18271) at a concentration of 0.3 µg/mL. The cell lysate was prepared with RIPA buffer and chemiluminescence was used for target detection.

Product Details

PA5-18271

Applications	Tested Dilution	Publications
Western Blot (WB)	0.3-1 µg/mL	-
Immunohistochemistry (IHC)	4.5 µg/mL	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Goat / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide sequence (TTLAGAVPRMM) corresponding to the N-terminus amino acids of PAX3 View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	TBS, pH 7.3, with 0.5% BSA
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_10978139

Product Specific Information

This antibody is predicted to react with bovine, mouse and rat based on sequence homology.

Target Information

Pax 3 (Paired Box 3) is a transcription factor that is involved in development of the peripheral nervous system, melanocytes, some vascular smooth muscle, and a number of other derivatives. It regulates neurogenesis in pre-migratory neural crest cells from the dorsal neural tube, and in myogenic progenitors in the presomitic mesoderm and the hypaxial somites. Alternative splicing results in isoforms having different C-termini.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HuP2; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778; paired box homeotic gene 3; Paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2

Gene Aliases: CDHS; HUP2; PAX3; WS1; WS3

UniProt ID: (Human) P23760

Entrez Gene ID: (Human) 5077

Function(s)

transcription from RNA polymerase II promoter apoptotic process nervous system development muscle organ development sensory perception of sound organ morphogenesis neural crest formation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter

Process(es)

transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding HMG box domain binding