This target displays homology in the following species: Cow: 100%; Dog: 100%; Goat: 86%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. Pax7 is expressed in muscle satellite cells. The satellite cells are required for tissue repair and regeneration following muscle injury, and Pax7 expression is required to maintain survival and proliferation of postnatal satellite cells in adults. The chromosomal translocation t(1;13)(p36;q14) with FOXO1 in alveolar rhabdomyosarcomas, results in PAX7-FOXO1 fusion protein which acts as a transcriptional activator. Alternative splicing yields 2 isoforms, PAX7-A (57 kDa) and PAX7-B (54 kDa) (PMID: 15527970).
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Protein Aliases: HUP1; paired box 7; paired box gene 7; paired box homeotic gene 7; Paired box protein Pax-7; paired box transcription factor PAX7; paired domain gene 7; PAX7 transcriptional factor; PAX7A; PAX7B; RMS2
Gene Aliases: HUP1; Pax-7; PAX7; PAX7B; RGD1564360; RMS2