This antibody can detect all 5 isoforms of PAX8 (31 kDa, 34 kDa, 41 kDa, 43 kDa, and 48 kDa). A 58-60 kDa form has also been reported. Proteintech's 10336-1-AP antibody has cross-reactivities with the other PAX family members.
This gene encodes a member of the paired box family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
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Protein Aliases: HGNC:8622; paired box gene 8; Paired box protein Pax-8; paired domain gene 8; Pax-8 protein
Gene Aliases: Pax-8; PAX8