This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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Recommended positive controls: 293T, 293T nuclear extract, DDDDK-tagged PAX8-transfected 293T.
Predicted reactivity: Mouse (98%), Rat (99%), Xenopus laevis (91%), Dog (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the paired box family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
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Protein Aliases: HGNC:8622; paired box gene 8; Paired box protein Pax-8; paired domain gene 8; Pax-8 protein
Gene Aliases: Pax-8; PAX8