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Proteintech
PBRM1 Polyclonal Antibody
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Product Details
12563-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PBRM1 Fusion Protein Ag3148 (1-306 aa encoded by BC015323)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGEEDSEVI EPPSLPQLQT PLASELDLMP YTPPQSTPKS AKGSAKKEGS KRKINMSGYI LFSSEMRAVI KAQHPDYSFG ELSRLVGTEW RNLETAKKAE YEGMMGGYPP GLPPLQGPVD GLVSMGSMQP LHPGGPPPHH LPPGVPGLPG IPPPGVMNQG VAPMVGTPAP GGSPYGQQVG VLGPPGQQAP PPYPGPHPAG PPVIQQPTTP MFVAPPPKTQ RLLHSEAYLK YIEGLSAESN SISKWDQTLA ARRRDVHLSK EQESRLPSHW LKSKGAHTTM ADALWRLRDL MLRDTLNIRQ AYNLENV (1-306 aa encoded by BC015323)
Target Information
The PBRM1 gene encodes a subunit of the PBAF (Polybromo-associated BAF) chromatin remodeling complex, playing a crucial role in the regulation of chromatin structure and transcription. PBRM1, also known as BAF180, contains bromodomains that recognize acetylated lysine residues on histone tails, facilitating chromatin remodeling necessary for effective transcriptional regulation. This gene is frequently mutated in renal cell carcinoma, particularly clear cell renal cell carcinoma (ccRCC), where such mutations are implicated in the pathogenesis of the disease. PBRM1 acts as a tumor suppressor, and its loss of function can lead to deregulation of gene expression, contributing to oncogenic processes. It is involved in pathways that govern cell cycle regulation and DNA damage response, reflecting its importance in maintaining genomic stability. Ongoing research focuses on understanding PBRM1's interactions within chromatin remodeling complexes and its potential as a therapeutic target in cancer treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2310032M22Rik; BAF180; BRG1-associated factor 180; hPB1; polybromo 1; Polybromo-1D; Protein polybromo-1
Gene Aliases: 2610016F04Rik; AI507524; BAF180; PB1; PBRM1; RGD1565549
UniProt ID: (Human) Q86U86
Entrez Gene ID: (Human) 55193, (Rat) 306254, (Mouse) 66923
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
mitotic nuclear division
negative regulation of cell proliferation
covalent chromatin modification
placenta development
heart development
biological_process
blood vessel remodeling
heart morphogenesis
epicardium-derived cardiac endothelial cell differentiation
chromatin modification
positive regulation of transcription, DNA-templated
cardiac vascular smooth muscle cell development
vasculogenesis involved in coronary vascular morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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