Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MDEQPRLMH SHAGVGMAGH PGLSQHLQDG AGGTEGEGGR KQDIGDILQQ IMTITDQSLD EAQARKHALN CHRMKPALFN VLCEIKEKTV LSIRGAQEEE PTDPQLMRLD NMLLAEGVAG PEKGGGSAAA AAAAAASGGA GSDNSVEHSD YRAKLSQIRQ IYHTELEKYE QACNEFTTHV MNLLREQSRT RPISPKEIER MVSIIHRKFS SIQMQLKQST CEAVMILRSR FLDARRKRRN FNKQATEILN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI RYKKNIGKFQ EEANIYAAKT AVTATNVSAH GSQANSPSTP NSAGSSSSFN MSNSGDLFMS (1-349 aa encoded by BC101578)
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1; 19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; OTTHUMP00000032205; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1
Gene Aliases: 2310056B04Rik; D230003C07Rik; Pbx-1; PBX1; PRL
UniProt ID: (Human) P40424, (Mouse) P41778
Entrez Gene ID: (Human) 5087, (Mouse) 18514, (Rat) 304947
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