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Invitrogen
PBX1 Polyclonal Antibody
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Product Details
PA5-19312
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (ATNVSAHGSQANSPS) corresponding to the internal amino acids of PBX1 (aa 313-327).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1; 19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; OTTHUMP00000032205; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1
Gene Aliases: 2310056B04Rik; D230003C07Rik; Pbx-1; PBX1; PRL
UniProt ID: (Human) P40424, (Mouse) P41778
Entrez Gene ID: (Human) 5087, (Mouse) 18514, (Rat) 304947
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein heterodimerization activity
transcription factor binding
sequence-specific DNA binding
molecular_function
homeodomain transcription factor
branching involved in ureteric bud morphogenesis
transcription from RNA polymerase II promoter
steroid biosynthetic process
sex differentiation
positive regulation of cell proliferation
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of G2/M transition of mitotic cell cycle
regulation of ossification
adrenal gland development
embryonic limb morphogenesis
somatic stem cell population maintenance
embryonic hemopoiesis
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
spleen development
thymus development
embryonic skeletal system development
urogenital system development
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
organ morphogenesis
cell differentiation
regulation of cell proliferation
negative regulation of sequence-specific DNA binding transcription factor activity
embryonic organ development
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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