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|Tested species reactivity||Dog, Fish, Human, Mouse, Rat, Zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide region of human PC4.|
|Storage buffer||PBS with 2% sucrose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||4-8 µg/ml|
|Immunoradiometric Assay (IRMA)||Assay-dependent|
|Western Blot (WB)||0.5-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24480 detects PC4 in Human samples.
PA1-24480 has been successfully used in Western Blot procedures.
PA1-24480 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human PC4.
PC4 (activated RNA polymerase II transcription cofactor 4) is a transcriptional coactivator, possessing the ability to suppress promoter-driven as well as nonspecific transcription via its DNA binding activity. The repressive activity of PC4 on promoter-driven transcription is alleviated by transcription factor TFIIH. TFIIH protects promoters from PC4-mediated repression by relieving the topological constraint imposed by PC4 through the ERCC3 helicase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
activated RNA polymerase II transcription cofactor 4; activated RNA polymerase II transcriptional coactivator p15; p14; PC4; positive cofactor 4; pR-ET2 encoded oncodevelopmental protein; RNA polymerase II transcriptional coactivator; single-stranded DNA-binding protein p9; SUB1 homolog; TIS7
AI842364; p14; P15; P9; PC4; RPO2TC1; SUB1; zgc:109973