Immunogen sequence: VSSSSSGSDS DSEVDKKLKR KKQVAPEKPV KKQKTGETSR ALSSSKQSSS SRDDNMFQIG KMRYVSVRDF KGKVLIDIRE YWMDPEGEMK PGRKGISLNP EQWSQLKEQI
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
PC4 (activated RNA polymerase II transcription cofactor 4) is a transcriptional coactivator, possessing the ability to suppress promoter-driven as well as nonspecific transcription via its DNA binding activity. The repressive activity of PC4 on promoter-driven transcription is alleviated by transcription factor TFIIH. TFIIH protects promoters from PC4-mediated repression by relieving the topological constraint imposed by PC4 through the ERCC3 helicase activity.
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Protein Aliases: activated RNA polymerase II transcription cofactor 4; Activated RNA polymerase II transcriptional coactivator p15; p14; PC4; Positive cofactor 4; SUB1 homolog; TIS7
Gene Aliases: p14; P15; PC4; RPO2TC1; SUB1
UniProt ID: (Human) P53999
Entrez Gene ID: (Human) 10923
Molecular Function: general transcription factor