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Immunogen sequence: EAARLEERR GVIEFHVVGN SLNQKPNKKI LMWLVGLQNV FSHQLPRMPK EYITRLVFDP KHKTLALIKD GRVIGGICFR MFPSQGFTEI VFCAVTSNEQ VKGYGTHLMN HLKEYHIKHD ILNFLTYADE YAIGYFKKQG FSKEIKIPKT KYVGYIKDYE GATLMGCELN PRIPYTEFSV IIKKQKEIIK KLIERKQAQI RKVYPGLSCF KDGVRQIPIE SIPGIRETGW KPSGKEKSKE PRDPDQLYST LKSILQQVKS HQSAWPFMEP VKRTEAPGYY EVIRFPMDLK TMSERLKNRY YVSKKLFMAD LQRVFTNCKE YNPPESEYYK CANILEKFFF SKIKEAGLID K (483-832 aa encoded by BC060823)
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
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Protein Aliases: CREBBP-associated factor; Histone acetylase PCAF; Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; Lysine acetyltransferase 2B; P/ PCAF; P/CAF; P300/CBP-associated factor; Spermidine acetyltransferase KAT2B
Gene Aliases: KAT2B; PCAF