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Proteintech
PCAF Polyclonal Antibody
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Product Details
13983-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PCAF Fusion Protein Ag5028 (483-832 aa encoded by BC060823)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Amount
27 µg
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EAARLEERR GVIEFHVVGN SLNQKPNKKI LMWLVGLQNV FSHQLPRMPK EYITRLVFDP KHKTLALIKD GRVIGGICFR MFPSQGFTEI VFCAVTSNEQ VKGYGTHLMN HLKEYHIKHD ILNFLTYADE YAIGYFKKQG FSKEIKIPKT KYVGYIKDYE GATLMGCELN PRIPYTEFSV IIKKQKEIIK KLIERKQAQI RKVYPGLSCF KDGVRQIPIE SIPGIRETGW KPSGKEKSKE PRDPDQLYST LKSILQQVKS HQSAWPFMEP VKRTEAPGYY EVIRFPMDLK TMSERLKNRY YVSKKLFMAD LQRVFTNCKE YNPPESEYYK CANILEKFFF SKIKEAGLID K (483-832 aa encoded by BC060823)
Target Information
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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