Proteintech

PCCB Polyclonal Antibody

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PCCB Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 11139-1-AP ( PCCB Antibody) at dilution of 1:200 (under 40x lens).

PCCB Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA)) — Immunofluorescent analysis of ( 4% PFA) fixed human kidney tissue using 11139-1-AP (PCCB antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

PCCB Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 11139-1-AP ( PCCB Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Details

11139-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:100-1:400	-
Immunohistochemistry (PFA fixed) (IHC (PFA))	1:50-1:500	-
Immunocytochemistry (ICC/IF)	1:50-1:500	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	PCCB Fusion Protein Ag1608 (240-539 aa encoded by BC013768) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.3 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: TQEELGGAK THTTMSGVAH RAFENDVDAL CNLRDFFNYL PLSSQDPAPV RECHDPSDRL VPELDTIVPL ESTKAYNMVD IIHSVVDERE FFEIMPNYAK NIIVGFARMN GRTVGIVGNQ PKVASGCLDI NSSVKGARFV RFCDAFNIPL ITFVDVPGFL PGTAQEYGGI IRHGAKLLYA FAEATVPKVT VITRKAYGGA YDVMSSKHLC GDTNYAWPTA EIAVMGAKGA VEIIFKGHEN VEAAQAEYIE KFANPFPAAV RGFVDDIIQP SSTRARICCD LDVLASKKVQ RPWRKHANIP L (240-539 aa encoded by BC013768)

Target Information

The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta; propionyl CoA carboxylase, beta polypeptide; propionyl Coenzyme A carboxylase, beta polypeptide; Propionyl-CoA carboxylase beta chain, mitochondrial

Gene Aliases: 1300012P06Rik; AI314687; PCCB; R74805

UniProt ID: (Human) P05166, (Mouse) Q99MN9

Entrez Gene ID: (Human) 5096, (Mouse) 66904, (Rat) 24624

Molecular Function: ligase metabolite interconversion enzyme