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Invitrogen
PCDGF Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
40-3400
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the C-terminal region of human PCDGF
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acrogranin; epithelin; glycoprotein 88; glycoprotein of 88 Kda; granulin-epithelin; granulins; PC cell-derived growth factor; proepithelin; unnamed protein product
Gene Aliases: CLN11; FTD2; GEP; GP88; PCDGF; PEPI; PGRN
UniProt ID: (Human) P28799
Entrez Gene ID: (Human) 2896
astrocyte activation involved in immune response
microglial cell activation involved in immune response
lysosome organization
lysosomal transport
lysosomal lumen acidification
signal transduction
positive regulation of cell proliferation
positive regulation of endothelial cell migration
positive regulation of cell migration
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
positive regulation of angiogenesis
negative regulation of innate immune response
positive regulation of axon regeneration
positive regulation of epithelial cell proliferation
regulation of inflammatory response
negative regulation of inflammatory response
regulation of developmental process
protein stabilization
positive regulation of cellular component organization
establishment of localization in cell
negative regulation of respiratory burst involved in inflammatory response
maintenance of synapse structure
positive regulation of inflammatory response to wounding
positive regulation of defense response to bacterium
negative regulation of neutrophil activation
positive regulation of protein folding
negative regulation of microglial cell activation
positive regulation of aspartic-type peptidase activity
positive regulation of lysosome organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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