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Invitrogen
PCGF1 Polyclonal Antibody
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FIGURE: 1 / 2
PCGF1 Antibody (PA5-49390) in WB
Western blot analysis of PCGF1 in lysates from human brain, mouse brain, mouse cerebellum, rat brain tissue (from left to right). Samples were incubated with PCGF1 polyclonal antibody (Product # PA5-49390) using a dilution of 1:1,000 followed by goat anti-rabbit IgG H&L (HRP) at a dilution of 1:10,000. Lysates at 20 µg per lane.
Product Details
PA5-49390
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 117-151 amino acids from the Central region of human PCGF1.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with bovine based on sequence homology.
Target Information
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: nervous system polycomb 1; Nervous system Polycomb-1; NSPc1; Polycomb group RING finger protein 1; RING finger protein 68
Gene Aliases: 2010002K04Rik; AU024121; NSPC1; PCGF1; RNF3A-2; RNF68
UniProt ID: (Human) Q9BSM1, (Mouse) Q8R023, (Rat) Q6DLV9
Entrez Gene ID: (Human) 84759, (Mouse) 69837, (Rat) 312480
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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