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Proteintech
PCMT1 Polyclonal Antibody
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Product Details
10519-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PCMT1 Fusion Protein Ag0811 (1-227 aa encoded by BC008748)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAWKSGGAS HSELIHNLRK NGIIKTDKVF EVMLATDRSH YAKCNPYMDS PQSIGFQATI SAPHMHAYAL ELLFDQLHEG AKALDVGSGS GILTACFARM VGCTGKVIGI DHIKELVDDS INNVRKDDPT LLSSGRVQLV VGDGRMGYAE EAPYDAIHVG AAAPVVPQAL IDQLKPGGRL ILPVGPAGGN QMLEQYDKLQ DGSIKMKPLM GVIYVPLTDK EKQWSRWK (1-227 aa encoded by BC008748)
Target Information
Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: L-isoaspartyl protein carboxyl methyltransferase; PIMT; protein carboxyl methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase; Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Gene Aliases: C79501; PCM; PCMT1; PIMT
UniProt ID: (Human) P22061, (Rat) P22062, (Mouse) P23506
Entrez Gene ID: (Human) 5110, (Rat) 25604, (Mouse) 18537
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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