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Invitrogen
PCP4 Polyclonal Antibody
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PCP4 Antibody (PA5-50188) in WB
Western Blot analysis of PCP4 was performed using Mouse heart tissue lysate. The membrane was probed with PCP4 Polyclonal Antibody (Product # PA5-50188) at dilution 1:500. Secondary antibody: (HRP-conjugated Goat anti rabbit IgG) at 1:5,000 dilution. Exposure time: 5 minutes.
Product Details
PA5-50188
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein corresponding to a region derived from internal residues of human purkinje cell protein 4
Conjugate
Form
Liquid
Concentration
2.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total PCP4 protein.
Target Information
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain specific polypeptide PEP19; Brain-specific antigen PCP-4; Brain-specific polypeptide PEP-19; Calmodulin regulator protein PCP4; Purkinje cell protein 4
Gene Aliases: P16Rimb19; Pcp-4; PCP4; PEP-19; PEP19; PEPZ19
UniProt ID: (Human) P48539, (Mouse) P63054, (Rat) P63055
Entrez Gene ID: (Human) 5121, (Mouse) 18546, (Rat) 25510
osteoblast differentiation
negative regulation of protein kinase activity
response to osmotic stress
central nervous system development
positive regulation of neuron projection development
positive regulation of dopamine secretion
negative regulation of neuron apoptotic process
cellular response to monosodium glutamate
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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