Immunogen sequence: IIVTCLMILY RLKERFQLSL RQDKEKNQEI HLSPITLQPA LSEAKTVHSM VQPEQAPKVL NVVVDPQGRG APEIKATTAT SVCPSPFKMK PIGLQERRGS NVSLTLDMSS LGNIEPFVSI PTPREKVAME YLQSASRILT RSQLRDVVAS SHLLQSEFME I; Positive Samples: U-87MG, HT-29, Rat heart; Cellular Location: Cell membrane, Cytoplasm, Single-pass type I membrane protein, perinuclear region, perinuclear region
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation.
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Protein Aliases: Ch-1 PTPase; Ch-1PTPase; ECPPT; NC-PTPCOM1; PC12-PTP1; Phosphotyrosine phosphatase 13; protein tyrosine phosphatase Cr1PTPase; protein tyrosine phosphatase PCPTP1; protein tyrosine phosphatase, receptor type, R; protein-tyrosine phosphatase NC-PTPCOM1; Protein-tyrosine phosphatase PCPTP1; Protein-tyrosine-phosphatase SL; protein-tyrosine-phosphatase-SL; R-PTP-R; Receptor-type tyrosine-protein phosphatase R; STEP-like PTPase; Tyrosine phosphatase CBPTP
Gene Aliases: EC-PTP; ECPTP; Gmcp1; mPTP213; PCPTP1; Ptp; PTP-SL; Ptp13; PTPBR7; PTPRQ; PTPRR; RPTPRR