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Invitrogen
PCSK1 Polyclonal Antibody
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Product Details
PA1-057
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues S(111) V Q K D S A L D L F N D P M W N(127) of mouse PC1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-057 detects prohormone convertase 1 (PC1) from mouse pituitary extract.
PA1-057 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~80 kDa protein representing PC1 from mouse pituitary extract.
The PA1-057 immunogen is a synthetic peptide corresponding to residues S(111) V Q K D S A L D L F N D P M W N(127) of mouse PC1. This sequence is 88% and 82% conserved bovine and rat, respectively. The PA1-057 immunizing peptide (Cat. # PEP-164) is available for use in neutralization and control experiments.
Target Information
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 3.4.21.93; Furin homolog; NEC 1; Neuroendocrine convertase 1; PC1; PC3; Prohormone convertase 1; prohormone convertase 1/3; Propeptide-processing protease; Proprotein convertase 1
Gene Aliases: Att-1; Nec-1; Nec1; PC1; PC3; Pcsk1; Phpp-1; SPC3
UniProt ID: (Mouse) P63239
Entrez Gene ID: (Mouse) 18548
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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