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Invitrogen
PCSK6 Polyclonal Antibody
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FIGURE: 1 / 2
PCSK6 Antibody (PA5-68543) in WB
Journal of orthopaedic surgery and research 2023 -
MiR-543 bound to PCSK6 in MH7A cells. A Starbase online database and GSE181614 dataset were used to predict mRNA with miR-543-binding sites. B The effects of miR-543 introduction on MMP3 and PCSK6 expression were determined by qRT-PCR in MH7A cells. C The effect of miR-543 mimics on PCSK6 protein expression was analyzed by western blotting assay. D RIP assay was used to identify the association of miR-543 w... View More
Product Details
PA5-68543
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N terminal region of human PCSK6
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 77%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%
Target Information
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Paired basic amino acid cleaving enzyme 4; paired basic amino acid cleaving system 4; Proprotein convertase subtilisin/kexin type 6; SPC4; Subtilisin-like proprotein convertase 4; Subtilisin/kexin-like protease PACE4
Gene Aliases: PACE4; PCSK6; SPC4
UniProt ID: (Human) P29122
Entrez Gene ID: (Human) 5046
proteolysis
zygotic determination of anterior/posterior axis, embryo
determination of left/right symmetry
glycoprotein metabolic process
protein processing
peptide hormone processing
regulation of BMP signaling pathway
nerve growth factor production
secretion by cell
plasma lipoprotein particle remodeling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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