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Proteintech
PCSK9 Polyclonal Antibody
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Product Details
27882-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PCSK9 Fusion Protein Ag27254
Conjugate
Form
Liquid
Concentration
350 µg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: convertase subtilisin; convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; OTTHUMP00000009833; PC9; Proprotein convertase 9; proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9; unnamed protein product
Gene Aliases: AI415265; AI747682; FH3; FHCL3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; PCSK9; PSEC0052
UniProt ID: (Human) Q8NBP7, (Rat) P59996, (Mouse) Q80W65
Entrez Gene ID: (Human) 255738, (Rat) 298296, (Mouse) 100102
RNA binding
serine-type endopeptidase activity
protein binding
peptidase activity
serine-type peptidase activity
hydrolase activity
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding
protein self-association
poly(A) RNA binding
serine protease
kidney development
liver development
negative regulation of receptor recycling
negative regulation of receptor internalization
positive regulation of receptor internalization
proteolysis
lipid metabolic process
triglyceride metabolic process
phospholipid metabolic process
apoptotic process
lysosomal transport
steroid metabolic process
cholesterol metabolic process
cellular response to starvation
negative regulation of low-density lipoprotein particle clearance
protein processing
protein autoprocessing
neurogenesis
neuron differentiation
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of sodium ion import across plasma membrane
negative regulation of receptor-mediated endocytosis involved in cholesterol transport
regulation of receptor activity
negative regulation of receptor activity
negative regulation of sodium ion transmembrane transporter activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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