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Product Details
PA5-55502
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PDCL3. Recombinant protein control fragment (Product #RP-92034).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2645320
Product Specific Information
Immunogen sequence: EWNDILRKKG ILPPKESLKE LEEEAEEEQR ILQQSVVKTY EDMTLEELED HEDEFNEEDE RAIEMYRRRR LAEWKATKLK
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.
Target Information
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling. PDCL3 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. Along with the related protein PDCL2, PDCL3 interacts with the chaperonin CCT and modulates CCT-mediated actin and tubulin folding. Modulation of PDCL3 levels by MAPK phosphorylation and RhoA-dependent changes also promote cytoskeletal remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HTPHLP; IAP-associated factor VIAF1; phosducin-like 3; Phosducin-like protein 3; PhPL3; VIAF-1; Viral IAP-associated factor 1
Gene Aliases: 1110061A19Rik; C80025; HTPHLP; PDCL3; PHLP2A; PHLP3; VIAF; VIAF1
UniProt ID: (Human) Q9H2J4, (Rat) Q4KLJ8, (Mouse) Q8BVF2
Entrez Gene ID: (Human) 79031, (Rat) 316348, (Mouse) 68833
angiogenesis
positive regulation of endothelial cell proliferation
protein folding
apoptotic process
queuosine biosynthetic process
viral process
positive regulation of angiogenesis
regulation of peptidyl-tyrosine phosphorylation
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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