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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.04-0.4 µg/mL | - |
Immunohistochemistry (IHC) |
1:200-1:500 | - |
Immunocytochemistry (ICC/IF) |
0.25-2 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant protein corresponding to Human PDCL3 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2645320 |
Immunogen sequence: EWNDILRKKG ILPPKESLKE LEEEAEEEQR ILQQSVVKTY EDMTLEELED HEDEFNEEDE RAIEMYRRRR LAEWKATKLK
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling. PDCL3 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. Along with the related protein PDCL2, PDCL3 interacts with the chaperonin CCT and modulates CCT-mediated actin and tubulin folding. Modulation of PDCL3 levels by MAPK phosphorylation and RhoA-dependent changes also promote cytoskeletal remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HTPHLP; IAP-associated factor VIAF1; phosducin-like 3; Phosducin-like protein 3; PhPL3; VIAF-1; Viral IAP-associated factor 1
Gene Aliases: 1110061A19Rik; C80025; HTPHLP; PDCL3; PHLP2A; PHLP3; VIAF; VIAF1
UniProt ID: (Human) Q9H2J4, (Rat) Q4KLJ8, (Mouse) Q8BVF2
Entrez Gene ID: (Human) 79031, (Rat) 316348, (Mouse) 68833
Molecular Function:
viral or transposable element protein
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