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Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; PDE10A; testis-specific phosphodiesterase PDE10A2
Gene Aliases: Pde10a; Pde10a3
UniProt ID: (Rat) Q9QYJ6
Entrez Gene ID: (Rat) 63885
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