|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:1000-1:10,000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 319 and 611 of Human PDE11A|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29113 targets PDE11A in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29113 immunogen is recombinant fragment corresponding to a region within amino acids 319 and 611 of Human PDE11A.
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5'-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; dual 3'; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; PPNAD2
Gene Aliases: PDE11A; PPNAD2
UniProt ID: (Human) Q9HCR9
Entrez Gene ID: (Human) 50940
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