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Product Details
12442-2-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Miscellaneous PubMed (Misc) |
- | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PDE1A Fusion Protein Ag3157 (185-545 aa encoded by BC022480) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.29 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: TRYDLINRF KIPVSCLITF AEALEVGYSK YKNPYHNLIH AADVTQTVHY IMLHTGIMHW LTELEILAMV FAAAIHDYEH TGTTNNFHIQ TRSDVAILYN DRSVLENHHV SAAYRLMQEE EMNILINLSK DDWRDLRNLV IEMVLSTDMS GHFQQIKNIR NSLQQPEGID RAKTMSLILH AADISHPAKS WKLHYRWTMA LMEEFFLQGD KEAELGLPFS PLCDRKSTMV AQSQIGFIDF IVEPTFSLLT DSTEKIVIPL IEEASKAETS SYVASSSTTI VGLHIADALR RSNTKGSMSD GSYSPDYSLA AVDLKSFKNN LVDIIQQNKE RWKELAAQGE SDLHKNSEDL VNAEEKHDET HS (185-545 aa encoded by BC022480)
Target Information
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1)that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3'-RACE clone 8 phosphodiesterase 1A; 3-RACE clone 8 phosphodiesterase 1A; 61 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; Cam-PDE 1A; Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; hCam-1; HS MGC26303; MGC26303; phosphodiesterase 1A, calmodulin-dependent; phosphodiesterase-1A
Gene Aliases: 3'-RACEclone8phosphodiesterase1A; 3-RACEclone8phosphodiesterase1A; AI987702; AW125737; CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; PDE1A
UniProt ID: (Human) P54750, (Mouse) Q61481
Entrez Gene ID: (Human) 5136, (Mouse) 18573, (Rat) 81529
Molecular Function:
phosphodiesterase
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
calmodulin binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
cGMP binding
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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