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Product Details
PA5-87915
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 446-545 of human PDE1A |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
2.68 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2804501 |
Product Specific Information
Immunogen sequence: EASKAETSSY VASSSTTIVG LHIADALRRS NTKGSMSDGS YSPDYSLAAV DLKSFKNNLV DIIQQNKERW KELAAQGESD LHKNSEDLVN AEEKHDETHS; Positive Samples: Mouse heart, Mouse brain, Mouse kidney, Rat heart, Rat brain
Target Information
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1)that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3'-RACE clone 8 phosphodiesterase 1A; 3-RACE clone 8 phosphodiesterase 1A; 61 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; Cam-PDE 1A; Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; hCam-1; HS MGC26303; MGC26303; phosphodiesterase 1A, calmodulin-dependent; phosphodiesterase-1A
Gene Aliases: 3'-RACEclone8phosphodiesterase1A; 3-RACEclone8phosphodiesterase1A; AI987702; AW125737; CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; PDE1A
UniProt ID: (Human) P54750, (Mouse) Q61481
Entrez Gene ID: (Human) 5136, (Mouse) 18573, (Rat) 81529
Molecular Function:
phosphodiesterase
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
calmodulin binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
cGMP binding
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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