Proteintech

PDE2A Polyclonal Antibody

PDE2A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PDE2A Antibody (55306-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 55306-1-AP (PDE2A Antibody) at dilution of 1:50 (under 40x lens).

PDE2A Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

55306-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.47 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to PDE2A.

Target Information

PDE2A (phosphodiesterase 2A) is a 100 kD cyclic nucleotide phosphodiesterase (PDE) and three isoforms of PDE2A have been reported (PDE2A1, PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localized in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Impaired Platelet Function and Thrombus Formation in PDE5A-Deficient Mice.

Thrombosis and haemostasis

Gui X,Chu X,Du Y,Wang Y,Zhang S,Ding Y,Tong H,Xu M,Li Y,Ju W,Sun Z,Li Z,Zeng L,Xu K,Qiao J

Wed Feb 01 00:00:00 UTC 2023

Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma.

Cells

Chen L,Zhou J,Zhao Z,Zhu Y,Xing J,An J,Guo X

Fri Dec 23 00:00:00 UTC 2022

Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma.

Cells

Chen L,Zhou J,Zhao Z,Zhu Y,Xing J,An J,Guo X

Fri Dec 23 00:00:00 UTC 2022

Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress.

Frontiers in pharmacology

Zhu X,Li T,Hu E,Duan L,Zhang C,Wang Y,Tang T,Yang Z,Fan R

Fri Feb 04 00:00:00 UTC 2022

Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation.

Cell reports

Pignatti E,Leng S,Yuchi Y,Borges KS,Guagliardo NA,Shah MS,Ruiz-Babot G,Kariyawasam D,Taketo MM,Miao J,Barrett PQ,Carlone DL,Breault DT

Tue Apr 21 00:00:00 UTC 2020

RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease.

Science advances

Eshraghi M,Ramírez-Jarquín UN,Shahani N,Nuzzo T,De Rosa A,Swarnkar S,Galli N,Rivera O,Tsaprailis G,Scharager-Tapia C,Crynen G,Li Q,Thiolat ML,Bezard E,Usiello A,Subramaniam S

Fri May 01 00:00:00 UTC 2020

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.

Communications biology

Lobo MJ,Reverte-Salisa L,Chao YC,Koschinski A,Gesellchen F,Subramaniam G,Jiang H,Pace S,Larcom N,Paolocci E,Pfeifer A,Zanivan S,Zaccolo M

Wed Oct 21 00:00:00 UTC 2020

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.

Communications biology

Lobo MJ,Reverte-Salisa L,Chao YC,Koschinski A,Gesellchen F,Subramaniam G,Jiang H,Pace S,Larcom N,Paolocci E,Pfeifer A,Zanivan S,Zaccolo M

Wed Oct 21 00:00:00 UTC 2020

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.

Communications biology

Lobo MJ,Reverte-Salisa L,Chao YC,Koschinski A,Gesellchen F,Subramaniam G,Jiang H,Pace S,Larcom N,Paolocci E,Pfeifer A,Zanivan S,Zaccolo M

Wed Oct 21 00:00:00 UTC 2020

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.

Communications biology

Lobo MJ,Reverte-Salisa L,Chao YC,Koschinski A,Gesellchen F,Subramaniam G,Jiang H,Pace S,Larcom N,Paolocci E,Pfeifer A,Zanivan S,Zaccolo M

Wed Oct 21 00:00:00 UTC 2020

17β-Estradiol reduces mitochondrial cAMP content and cytochrome oxidase activity in a phosphodiesterase 2-dependent manner.

British journal of pharmacology

Pozdniakova S,Guitart-Mampel M,Garrabou G,Di Benedetto G,Ladilov Y,Regitz-Zagrosek V

Mon Oct 01 00:00:00 UTC 2018

17β-Estradiol reduces mitochondrial cAMP content and cytochrome oxidase activity in a phosphodiesterase 2-dependent manner.

British journal of pharmacology

Pozdniakova S,Guitart-Mampel M,Garrabou G,Di Benedetto G,Ladilov Y,Regitz-Zagrosek V

Mon Oct 01 00:00:00 UTC 2018

Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity.

JCI insight

Liu K,Li D,Hao G,McCaffary D,Neely O,Woodward L,Ioannides D,Lu CJ,Brescia M,Zaccolo M,Tandri H,Ajijola OA,Ardell JL,Shivkumar K,Paterson DJ

Thu May 03 00:00:00 UTC 2018

Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity.

JCI insight

Liu K,Li D,Hao G,McCaffary D,Neely O,Woodward L,Ioannides D,Lu CJ,Brescia M,Zaccolo M,Tandri H,Ajijola OA,Ardell JL,Shivkumar K,Paterson DJ

Thu May 03 00:00:00 UTC 2018

Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.

Biochemical pharmacology

Módis K,Panopoulos P,Coletta C,Papapetropoulos A,Szabo C

Fri Nov 01 00:00:00 UTC 2013

Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.

Biochemical pharmacology

Módis K,Panopoulos P,Coletta C,Papapetropoulos A,Szabo C

Fri Nov 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; CGS-PDE; cGSPDE; cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; phosphodiesterase 2A, cGMP-stimulated

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Gene Aliases: CGS-PDE; cGSPDE; Pde2; PDE2A; PDE2A1; Pde2a2; PED2A4

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UniProt ID: (Human) O00408, (Rat) Q01062, (Mouse) Q922S4

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Entrez Gene ID: (Human) 5138, (Rat) 81743, (Mouse) 207728

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Function(s)

cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity calcium channel activity protein binding drug binding cAMP binding cGMP binding TPR domain binding protein homodimerization activity metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity GAF domain binding nucleotide binding 3',5'-cyclic-nucleotide phosphodiesterase activity phosphoric diester hydrolase activity hydrolase activity phosphodiesterase

Process(es)

negative regulation of transcription from RNA polymerase II promoter cAMP catabolic process protein targeting to mitochondrion metabolic process cAMP-mediated signaling cGMP-mediated signaling negative regulation of cAMP biosynthetic process negative regulation of protein import into nucleus, translocation cellular response to drug cellular response to macrophage colony-stimulating factor stimulus negative regulation of vascular permeability positive regulation of vascular permeability cGMP catabolic process positive regulation of inflammatory response establishment of endothelial barrier calcium ion transmembrane transport cellular response to mechanical stimulus cellular response to cGMP cellular response to transforming growth factor beta stimulus positive regulation of gene expression monocyte differentiation regulation of cGMP metabolic process cellular response to granulocyte macrophage colony-stimulating factor stimulus signal transduction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PDE2A Polyclonal Antibody

PDE2A Antibody (55306-1-AP) in IHC (P)

Product Details

55306-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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