Proteintech

PDE2A Polyclonal Antibody

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PDE2A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 55306-1-AP (PDE2A Antibody) at dilution of 1:50 (under 40x lens).

PDE2A Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 55306-1-AP (PDE2A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

PDE2A Antibody in Immunoprecipitation (IP) — IP result of anti-PDE2A (IP:55306-1-AP, 4ug; Detection:55306-1-AP 1:500) with mouse brain tissue lysate 3440ug.

Product Details

55306-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 3 publications 3 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Peptide
Conjugate	Unconjugated
Form	Liquid
Concentration	0.47 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

This antibody is specific to PDE2A.

Target Information

PDE2A (phosphodiesterase 2A) is a 100 kD cyclic nucleotide phosphodiesterase (PDE) and three isoforms of PDE2A have been reported (PDE2A1, PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localized in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

17β-Estradiol reduces mitochondrial cAMP content and cytochrome oxidase activity in a phosphodiesterase 2-dependent manner.

British journal of pharmacology

Pozdniakova S,Guitart-Mampel M,Garrabou G,Di Benedetto G,Ladilov Y,Regitz-Zagrosek V

Mon Oct 01 00:00:00 EDT 2018

Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity.

JCI insight

Liu K,Li D,Hao G,McCaffary D,Neely O,Woodward L,Ioannides D,Lu CJ,Brescia M,Zaccolo M,Tandri H,Ajijola OA,Ardell JL,Shivkumar K,Paterson DJ

Thu May 03 00:00:00 EDT 2018

Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.

Biochemical pharmacology

Módis K,Panopoulos P,Coletta C,Papapetropoulos A,Szabo C

Fri Nov 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; CGS-PDE; cGSPDE; cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; phosphodiesterase 2A, cGMP-stimulated

Gene Aliases: CGS-PDE; cGSPDE; Pde2; PDE2A; PDE2A1; Pde2a2; PED2A4

UniProt ID: (Human) O00408, (Rat) Q01062, (Mouse) Q922S4

Entrez Gene ID: (Human) 5138, (Rat) 81743, (Mouse) 207728

Molecular Function: phosphodiesterase